Haruhiko Akiyama Selected Research

4- N,N- dimethylamino- 1- naphthylisothiocyanate

2/2011	Clinicopathological study of diffuse neurofibrillary tangles with calcification. With special reference to TDP-43 proteinopathy and alpha-synucleinopathy.
8/2005	Argyrophilic grains are not always argyrophilic--distinction from neurofibrillary tangles of diffuse neurofibrillary tangles with calcification revealed by comparison between Gallyas and Campbell-Switzer methods.
7/2005	Distribution of cerebral cortical lesions in diffuse neurofibrillary tangles with calcification: a clinicopathological study of four autopsy cases showing prominent parietal lobe involvement.

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Haruhiko Akiyama Research Topics

Disease

41	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 12/2022 - 12/2006
30	Alzheimer Disease (Alzheimer's Disease) 02/2018 - 05/2003
24	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 10/2020 - 07/2002
15	Frontotemporal Dementia (Semantic Dementia) 10/2020 - 05/2003
15	Dementia (Dementias) 07/2017 - 09/2003
13	Osteoarthritis 11/2022 - 12/2008
10	TDP-43 Proteinopathies 10/2020 - 11/2008
8	Neoplasms (Cancer) 01/2019 - 05/2012
8	Atrophy 08/2017 - 07/2005
7	Sarcoma (Soft Tissue Sarcoma) 12/2022 - 09/2012
7	Synucleinopathies 01/2017 - 11/2012
7	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2017 - 02/2006
6	Pain (Aches) 11/2022 - 01/2013
6	Disease Progression 01/2021 - 12/2002
6	Tauopathies 01/2017 - 08/2005
6	Parkinson Disease (Parkinson's Disease) 08/2014 - 02/2006
5	Osteonecrosis (Kienbock's Disease) 01/2021 - 11/2010
5	Corticobasal Degeneration 01/2017 - 05/2003
5	Amyloid Plaque 12/2015 - 08/2009
4	Inflammation (Inflammations) 05/2017 - 04/2004
4	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 08/2013 - 05/2003
3	Infections 05/2021 - 01/2018
3	Hip Osteoarthritis (Coxarthrosis) 01/2020 - 01/2014
3	Schizophrenia (Dementia Praecox) 12/2019 - 04/2008
3	Knee Osteoarthritis 11/2018 - 02/2016
3	Diffuse Neurofibrillary Tangles with Calcification 02/2011 - 07/2005
2	Synovitis 07/2022 - 09/2014
2	Heterotopic Ossification (Ectopic Ossification) 03/2022 - 09/2019
2	Neoplasm Metastasis (Metastasis) 08/2021 - 07/2017
2	Osteosarcoma (Osteogenic Sarcoma) 08/2021 - 04/2016
2	Multiple Hereditary Exostoses (Hereditary Multiple Exostoses) 05/2021 - 03/2016
2	Arthritis (Polyarthritis) 01/2020 - 08/2017
2	Postoperative Hemorrhage 09/2019 - 01/2018
2	Hematoma 09/2018 - 08/2017
2	Osteoporosis 01/2018 - 02/2009
2	Adenocarcinoma 01/2018 - 01/2018
2	Proteostasis Deficiencies 01/2017 - 11/2012
2	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 01/2017 - 06/2006
2	Hemorrhage 01/2017 - 06/2016
2	Cysts 01/2017 - 03/2014
2	Stress Fractures (Stress Fracture) 11/2016 - 03/2014
2	Neuroblastoma 03/2016 - 09/2006
2	Astrocytoma (Pilocytic Astrocytoma) 12/2015 - 10/2007
2	Multiple System Atrophy 08/2014 - 09/2009
2	Huntington Disease (Huntington's Disease) 03/2014 - 09/2009
2	Hypertrophy 11/2011 - 12/2008
2	Pick Disease of the Brain (Pick's Disease) 04/2009 - 05/2003
2	Amyloid angiopathy 11/2004 - 09/2003

Drug/Important Bio-Agent (IBA)

25	UbiquitinIBA 12/2022 - 07/2002
22	DNA-Binding Proteins (DNA Binding Protein)IBA 10/2020 - 12/2006
21	Proteins (Proteins, Gene)FDA Link 12/2022 - 01/2004
10	SynucleinsIBA 01/2016 - 02/2007
9	Amyloid (Amyloid Fibrils)IBA 01/2017 - 09/2003
8	sarkosylIBA 06/2018 - 07/2008
8	Amyloid beta-PeptidesIBA 02/2018 - 09/2003
7	AntibodiesIBA 01/2012 - 09/2003
6	Biomarkers (Surrogate Marker)IBA 07/2017 - 07/2009
5	Protein Isoforms (Isoforms)IBA 01/2017 - 09/2006
4	ProgranulinsIBA 02/2018 - 11/2008
4	PrionsIBA 01/2016 - 01/2012
3	CollagenIBA 12/2022 - 06/2007
3	tau Proteins (tau Protein)IBA 12/2019 - 08/2005
3	Anti-Bacterial Agents (Antibiotics)IBA 07/2019 - 07/2007
3	GranulinsIBA 02/2018 - 02/2015
3	Peptide Hydrolases (Proteases)FDA Link 01/2018 - 11/2010
3	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 01/2018 - 01/2016
3	Transcription Factors (Transcription Factor)IBA 11/2015 - 12/2013
3	Biological ProductsIBA 08/2015 - 02/2012
3	4- N,N- dimethylamino- 1- naphthylisothiocyanateIBA 02/2011 - 07/2005
2	Protein AggregatesIBA 12/2022 - 12/2013
2	4-(N-maleimido)benzyltrimethylammonium (MPTA)IBA 09/2022 - 10/2019
2	exostosin-1IBA 05/2021 - 03/2016
2	exostosin-2IBA 05/2021 - 03/2016
2	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 01/2021 - 11/2010
2	A-factor (Streptomyces)IBA 01/2020 - 10/2016
2	GelatinIBA 08/2016 - 01/2016
2	HydrogelsIBA 08/2016 - 01/2016
2	EpitopesIBA 08/2013 - 01/2012
2	alpha-SynucleinIBA 11/2012 - 04/2008
2	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 06/2012 - 09/2006
2	Pharmaceutical PreparationsIBA 01/2012 - 01/2011
2	Methylene Blue (Methylthioninium Chloride)FDA Link 01/2012 - 07/2009
2	EnzymesIBA 06/2009 - 09/2006
2	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 11/2008 - 05/2003
1	neurochondrinIBA 12/2022
1	RNA-Binding Proteins (RNA-Binding Protein)IBA 12/2022

Therapy/Procedure

12	Therapeutics 01/2020 - 04/2010
7	Osteotomy 01/2021 - 05/2011
4	Arthroplasty 11/2022 - 04/2020
4	Decompression 01/2022 - 01/2016
4	Arthrodesis 01/2021 - 12/2009
4	Hip Replacement Arthroplasty (Total Hip Replacement) 01/2016 - 12/2008
3	Knee Replacement Arthroplasty (Total Knee Replacement) 09/2022 - 06/2016
3	Reoperation 03/2022 - 09/2019
2	Transplantation 01/2022 - 01/2020
2	Adjuvant Chemotherapy 08/2021 - 07/2017
2	Laminoplasty 09/2018 - 01/2018
2	Resistance Training 06/2017 - 01/2014
2	Activities of Daily Living (ADL) 01/2017 - 12/2009
2	Mechanical Ventilators (Ventilator) 09/2004 - 12/2002